Mesenchymal Stem Cells Knee Osteoarthritis

Numerous systematic reviews investigating the effects of mesenchymal stem cells mscs in treating knee osteoarthritis oa have been published with controversial conclusion.

Mesenchymal stem cells knee osteoarthritis.

Stem cell therapy is seen as a potential new approach to the treatment of a range of chronic disease states. However cell expansion makes the procedure slow and expensive. This perspective will discuss progress being made with the use of mesenchymal stem cells for the treatment of osteoarthritis oa with particular reference to current studies and the published literature to assess the potential of this emerging area of medicine. Osteoarthritis is a degenerative joint disease characterized by the destruction of joint cartilage.

Knee osteoarthritis oa is a common skeletal impairment that can cause many limitations in normal life activities. We investigated the safety and efficacy of intra articular injection of placental mesenchymal stem cells mscs in knee oa healing. Stem cell therapy has been studied for decades for its regenerative potency in various diseases. Allogeneic cells would be cheaperand logistically moreconvenient themostobvious disadvantage of using these cells is the possibility of host immune rejection.

Knee osteoarthritis is a common condition that happens when the cartilage that cushions the knee joint starts to wear down. The purpose of the overview was 1 to perform an overview of systematic reviews investigating mscs for knee oa and 2 to synthesize evidence qualitatively to assess. If successful intra articular mesenchymal stem cell msc injections into the knee may offer another viable non operative treatment modality. Mesenchymal stem cells mscs are found in low numbers in normal cartilage mainly in the superficial layer acting as repairing agents.

Stem cells are considered to be one of the greatest potential treatments to cure degenerative diseases. Many patients with osteoarthritis of the knee fail non operative measures and elect to have knee arthroplasty to improve their quality of life. Nikbinmesenchymal stem cell therapy for knee osteoarthritis. Mesenchymal stromal cells however are immune privileged7 or immune evasive8 and inhibit.

Stem cells injection for knee osteoarthritis oa is still a relatively new treatment and has not yet gained popularity.